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Why All The Fuss? The Problem of Multidrug Resistance

With the ever-increasing problem of multidrug-resistant organisms, the Centers for Medicare & Medicaid Services have taken notice in hospitals and nursing homes.^1,2 Aside from this, more medications (especially antibiotics) create more problems. Often the side effects of antibiotic usage are difficult to manage or require more antibiotic usage, such as in cases of Clostridium difficile infection. If we are to reduce antibiotic usage we need to know what tools in our tool kit are safe and effective for all age ranges and situations. Hypochlorous acid meets these criteria. In a published scientific article describing a study in which hypochlorous acid was tested to look at a variety of its components, the outcome determined that this solution in most cases had a 12-second kill time for numerous bacteria and viruses, helped promote wound healing and cell proliferation, and did not harm current healthy cells. Also of note, this solution disrupted biofilm and increased cell migration.³ What’s not to like?

What’s the Down Side of Hypochlorous Acid?

Hypochlorous acid is more expensive than saline. Based on the product, some preparations have a rather short shelf life after opening (i.e., 24 hours to 30 days), so research the product before purchase to ensure that it meets your expectations and needs. Some preparations have a shelf life of 18 months after opening. Hypochlorous acid cannot be combined with silver products because the two cancel each other out through the power of oxidization. If you add up the cost associated with antibiotics, the costs of treating the side effects of antibiotics, and the cost of silver products, in general, there are significant cost savings associated with the use of hypochlorous acid (depending on the price of the hypochlorous acid preparation you use, of course). If you do a quick review, we are meeting CMS mandates, reducing antibiotic usage, reducing silver usage, not contributing to the multidrug-resistant organism dilemma, disrupting biofilm, and using a non-cytotoxic agent. I guess it really may be considered an ideal agent for wounds after all.

References
1. CMS’ proposed rule for hospitals: reduce antibiotic use or exit Medicare. Becker’s Hospital Review. https://www.beckershospitalreview.com/quality/cms-proposed-rule-for-hosp…. Published June 14, 2016. Accessed February 1, 2018.
2. Dall C. New rule mandates antibiotic stewardship in nursing homes. CIDRAP Center for Infection Disease Research and Policy. http://www.cidrap.umn.edu/news-perspective/2016/10/new-rule-mandates-ant…. Published October 4, 2016. Accessed February 1, 2018.
3. Sakarya S, Gunay N, Karakulak M, Ozturk B, Ertugrul B. Hypochlorous acid: an ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency. Wounds. 2014;26(12):342-50.